Running Home Assistant OS in a virtual machine using the provided VM images is a supported configuration.

From ADR-0015: Installation Method: Home Assistant OS:

Supported Hypervisors

The Home Assistant Operating System can be run on a Hypervisor and thus be run as a virtual machine. The following Hypervisors are supported:

• KVM/QEMU
• VirtualBox
• VMWare
• Xen

We will provide documentation for the following systems build on top of these technologies:

• Proxmox (KVM/QEMU based)
• Unraid (KVM/QEMU based)
• VirtualBox
• VMWare