Brain's Weight Switch Found: May Let Us Eat What We Want, Finally - eviltoast

A new discovery reveals that astrocytes, star-shaped cells in the brain, play a key role in regulating fat metabolism and obesity. These cells act on a cluster of neurons, known as the GABRA5 cluster, effectively acting as a “switch” for weight regulation.

The MAO-B enzyme in these astrocytes was identified as a target for obesity treatment, influencing GABA secretion and thus weight regulation.

KDS2010, a selective and reversible MAO-B inhibitor, successfully led to weight loss in obese mice without impacting their food intake, even while consuming a high-fat diet, and is now in Phase 1 clinical trials.

  • CanadaPlus@lemmy.sdf.org
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    1 year ago

    That’s the bit they mentioned, anyway. It sounds like in this scenario they tried two different diets, and the higher-calorie one produced more body heating. I imagine appetite regulation would also play a part “in the wild”.