How about we play, "Never have I ever"? - eviltoast

Here’s the rules:

1: Post something you have never done that you think many people do. 2: Read the other posts, if you have done that thing, upvote it. If you have not done that thing, downvote it. 3: If you believe the person is lying, call them out on it in a reply. 4: If you are called out, give the full story. 4a: If you see a thread containing the full story, boost the person you think is right and truthful.

Person who has the most upvotes when the thread dies wins.

  • deranger@sh.itjust.works
    2·
    2 months ago

    With alcohol it’s very clear that there’s one organ doing the heavy lifting

    It’s not your liver, it’s your GABA receptors downregulating that gives you a tolerance. Your liver helps with the duration and hangover but the lower peak intoxication is mediated by the receptors. Likewise with cannabis, your THC receptors downregulate to give you a weed tolerance. It is also processed by the liver.