On Earth, the cardinal directions are straightforward. The arrow on a compass points to the nearest magnetic pole. You can then use it to travel anywhere on Earth.
In space, the idea of anything being “central” enough to be used as a “North” (since the universe has no center) or being fixated enough to not somehow pose issues is more convoluted.
If you were a pioneer of space exploration, what would your “North” be?
The rotation axis of the Milky Way. It seems more reliable for me than to pick two astronomical objects, as their direction might change over time. Plus it makes intuitive sense considering how we did it for Earth.