Question on KernelSU (LKM) and updates - eviltoast

By now, most people in the custom ROM community must have already heard of KernelSU. I do think that it is worth the hype and is truly revolutionary, piggybacking on something I credit Google on (to some personal chagrin) - KMI.

The question I have is: when I attempt to install OTA updates to a device with KernelSU running as a Kernel module, will that affect KernelSU? Will I have to root again?