Best BTRFS setup for Debian 12 server - eviltoast

Just received 2 SSD for OS+Apps and 2 HDD (2x the size of the SSDs) for backups.

I will use Debian 12 to serve a few VMs and i’m thinking on using btrfs with RAID1 and encryption for the set of SSDs and for the set of HDDs.

I’m thinking on using a non-encrypted boot partition and md for swap and the rest of the drives for encrypted raid1 with btrfs.

Any hints or suggestion for the storage layout ?