Keygens/Patches/Cracks - eviltoast

Ok, I need some insight before I go back into Torrenting. I need a piece of software from a less than reputable company (Wondershare). Now I know Keygens can be run through Sandboxie or a VM to get the key but how do Patches and Cracks work?

One of TorrentGalaxy’s most trusted uploaders & software patchers keeps the software updated and uploaded & includes in the download listing the www.virustotal.com report for the installation files which shows a clean listing; however the Patch shows a listing for multiple AV/Malware software which shows the Patch being a virus. So, how do I use the software if the Patch is “infected”. Am I missing something? Thanks!